{"title":"Hemoglobinopathies","description":"\u003cp class=\"p1\"\u003eHemoglobinopathies are \u003cspan class=\"s1\"\u003e\u003cb\u003einherited blood disorders caused by abnormalities in the structure or production of hemoglobin\u003c\/b\u003e\u003c\/span\u003e, the protein in red blood cells responsible for carrying oxygen. Common hemoglobinopathies include \u003cspan class=\"s1\"\u003e\u003cb\u003eSickle Cell Disease, Thalassemia, and Hemoglobin variants such as HbE and HbC\u003c\/b\u003e\u003c\/span\u003e. These conditions can lead to \u003cspan class=\"s1\"\u003e\u003cb\u003eanemia, fatigue, delayed growth, infections, and organ complications\u003c\/b\u003e\u003c\/span\u003e. Early screening, accurate diagnosis, genetic counseling, and appropriate clinical management are essential to reduce disease severity and improve quality of life.\u003c\/p\u003e","products":[{"product_id":"sickle-cell-rapid-test","title":"SICKLE CELL RAPID TEST","description":"\u003cp\u003e\u003cspan\u003eThe Sickle Cell Rapid Test is a diagnostic tool designed to detect specific hemoglobin variants in the blood, including HbA (normal hemoglobin), HbS (sickle hemoglobin), and HbC. Identifying these hemoglobin variants is crucial for diagnosing sickle cell disease and related conditions. Detection of HbS and HbC is particularly significant as they are associated with different types of sickle cell disease. Early and accurate detection is vital for timely medical intervention and management. This test offers numerous benefits, especially in carrier testing. It can identify individuals who carry the sickle cell trait (heterozygous for HbS) or other hemoglobinopathies like HbC, allowing for informed family planning decisions and genetic counseling. Early identification and counseling empower carriers to make informed choices about their reproductive options, reducing the risk of having children with severe forms of the disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCheck \u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/ENCORE_-_SICKLE_CELL_-_EN_-VER_02.pdf?v=1767255798\" title=\"Encore Sickle Cell\" rel=\"noopener\" style=\"color: rgb(255, 42, 0);\" target=\"_blank\"\u003eHERE \u003c\/a\u003e\u003c\/span\u003eInstructions For Use (Pack Insert)\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Enssure","offers":[{"title":"10 TESTS \/ Exp.: JAN 2028","offer_id":51679799312683,"sku":null,"price":850.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/SC-06.jpg?v=1773118860"},{"product_id":"sickle-cell-solubility-test","title":"SICKLE CELL SOLUBILITY","description":"\u003cp\u003e\u003cspan\u003eHemoglobin S (Hb S) differs from normal Hemoglobin A (Hb A) by a single amino acid change—valine replaces glutamic acid at position 6 of the beta chain. This causes red blood cells to become sickle-shaped under low oxygen conditions, leading to blood vessel blockages and anemia. Individuals with sickle cell anemia (S\/S) face severe symptoms and early mortality, while those with the trait (NS) are usually asymptomatic but may experience crises under low oxygen conditions. The Sickle Cell Solubility Test is based on the solubility difference between Hb S and Hb A in concentrated phosphate buffer solution. This reliable screening method enables healthcare providers to quickly identify the presence of hemoglobin S, facilitating early diagnosis and appropriate patient management. The test utilizes sodium dithionite in concentrated phosphate buffer to cause Hb S precipitation while keeping Hb A soluble, providing clear visual differentiation between normal and abnormal hemoglobin variants.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCheck \u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/ENCORE_-_SICKLE_SOLUBILITY.pdf?v=1767335315\" rel=\"noopener\" style=\"color: rgb(255, 42, 0);\" target=\"_blank\"\u003eHERE \u003c\/a\u003e\u003c\/span\u003eInstructions For Use (Pack Insert)\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv class=\"product-form__input product-form__quantity product-form__quantity-top\" id=\"Quantity-Form-template--26031733440811__main\"\u003e\u003c\/div\u003e","brand":"Enssure","offers":[{"title":"50 TESTS \/ Exp.: JAN 2028 \/ Exp.: FEB. 2028","offer_id":51679740166443,"sku":null,"price":750.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/SICKELCELLSOLUBITI-01.jpg?v=1773118777"},{"product_id":"g6pdh","title":"G6PDH","description":"\u003cp\u003e\u003cspan\u003eGlucose-6-phosphate dehydrogenase (G6PD) deficiency is a hereditary disorder caused by a defect in the G6PD enzyme, crucial for protecting red blood cells from oxidative damage. This enzyme is essential in the pentose phosphate pathway, where it helps produce NADPH, needed to maintain reduced glutathione, a key antioxidant. Without sufficient NADPH, red blood cells become vulnerable to oxidative stress, leading to hemolysis. The condition is X-linked, primarily affecting males. Females with two defective gene copies (homozygous or compound heterozygous) can also show symptoms, while most heterozygous females are asymptomatic carriers. Triggers like fava beans, aspirin, or sulfonamides can cause acute hemolytic anemia, presenting as jaundice, fatigue, shortness of breath, or in severe cases, shock. The G6PDH test uses glucose-6-phosphate substrate colorimetric method with nitrotetrazolium blue chloride (NBT) to detect enzyme activity through visual color formation. Measuring G6PD enzyme activity is crucial for diagnosis and management, enabling healthcare providers to identify at-risk patients and prevent hemolytic episodes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003eCheck \u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/ENCORE_-_G6PD_-_VER_01.pdf?v=1767334670\" rel=\"noopener\" style=\"color: rgb(255, 42, 0);\" target=\"_blank\"\u003eHERE \u003c\/a\u003e\u003c\/span\u003eInstructions For Use (Pack Insert)\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Enssure","offers":[{"title":"10 TESTS \/ Exp.: APR. 2027","offer_id":51679591596331,"sku":null,"price":800.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/files\/G6-05.jpg?v=1766730892"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0973\/1827\/3323\/collections\/sickel_cell_solubility.jpg?v=1766582497","url":"https:\/\/shop.encorebiomedicals.com\/collections\/hemoglobinopathies.oembed","provider":"Encore Biomedicals ","version":"1.0","type":"link"}