1 3

G6PDH

G6PDH

Rs. 800.00
Rs. 2,500.00 Rs. 800.00
Rs. 80.00 each
Sale Sold out
Shipping calculated at checkout.

PACKS
Product Expiry

Batch Details

Lot No. : 047/05/2025/002
Mfg. : 05/2025
Exp. : 04/2027

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hereditary disorder caused by a defect in the G6PD enzyme, crucial for protecting red blood cells from oxidative damage. This enzyme is essential in the pentose phosphate pathway, where it helps produce NADPH, needed to maintain reduced glutathione, a key antioxidant. Without sufficient NADPH, red blood cells become vulnerable to oxidative stress, leading to hemolysis. The condition is X-linked, primarily affecting males. Females with two defective gene copies (homozygous or compound heterozygous) can also show symptoms, while most heterozygous females are asymptomatic carriers. Triggers like fava beans, aspirin, or sulfonamides can cause acute hemolytic anemia, presenting as jaundice, fatigue, shortness of breath, or in severe cases, shock. The G6PDH test uses glucose-6-phosphate substrate colorimetric method with nitrotetrazolium blue chloride (NBT) to detect enzyme activity through visual color formation. Measuring G6PD enzyme activity is crucial for diagnosis and management, enabling healthcare providers to identify at-risk patients and prevent hemolytic episodes.

 

Check HERE Instructions For Use (Pack Insert)
View full details

Importance to know

  • Warnings and Precautions

    • Please read the instruction carefully before performing the test.
    • Do not use the test after the expiration date.
    • Immediately carry out the test after removing the test device from the pouch.
    • Do not mix or interchange the specimen sample.
    • This test is intended for screening purposes only and should be confirmed with additional testing methods.
    • Handle blood samples with care and follow universal precautions for bloodborne pathogens.
    • Avoid exposure to excessive heat or light during testing as it may affect enzyme activity.

    Limitation

  • Limitation

    • For in vitro diagnostic use only; detects G6PD enzyme activity in whole blood samples.
    • This test should not be used as the sole criterion for the diagnosis of G6PD deficiency.
    • If the test result is negative and clinical symptoms persist, additional follow-up testing using quantitative enzyme assays is recommended.
    • A negative result does not preclude the possibility of other enzyme deficiencies or blood disorders.
    • Clinical correlation and additional diagnostic procedures are recommended for proper patient management and genetic counseling.
    • Test results may be affected by recent blood transfusions, which can mask G6PD deficiency in recipients.
    • Newborns and patients with reticulocytosis may show false normal results due to higher enzyme activity in young red blood cells.